Possible food and drug interactions when taking Cipro

Consumer Information (PDR)

Serious and fatal reactions have occurred when Cipro was taken in combination with theophylline (Theo-Dur). These reactions have included cardiac arrest, seizures, status epilepticus (continuous attacks of epilepsy with no periods of consciousness), and respiratory failure.

The following can interfere with the absorption of Cipro and should be taken no less than 6 hours before or 2 hours after a dose:

Antacids containing magnesium and aluminum
Carafate
Supplements and other products containing calcium, iron, or zinc
Videx chewable tablets and pediatric powder

You should also avoid taking Cipro with milk or yogurt alone, though calcium taken as part of a full meal has no significant effect on the drug.

Cipro may increase the effects of caffeine.

If Cipro is taken with certain other drugs, the effects of either could be increased, decreased, or altered. These drugs include:

Cyclophosphamide (Cytoxan)
Cyclosporine (Sandimmune, Neoral)
Glyburide (DiaBeta, Glynase, Micronase)
Methotrexate (Rheumatrex)
Metoclopramide (Reglan)
Metoprolol (Lopressor)
Phenytoin (Dilantin)
Probenecid
Warfarin (Coumadin)

Certain nonsteroidal anti-inflammatory drugs (NSAIDs), with the exception of aspirin, could cause convulsions when combined with high doses of this type of antibiotic.

Consumer Information (Cerner Multum)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For the fluoroquinolones, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to any of the fluoroquinolones or to any related medicines such as cinoxacin (e.g., Cinobac) or nalidixic acid (e.g., NegGram). Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy—Studies have not been done in humans. However, use is not recommended during pregnancy since fluoroquinolones have been reported to cause bone development problems in young animals.

Breast-feeding—Some of the fluoroquinolones are known to pass into human breast milk. Since fluoroquinolones have been reported to cause bone development problems in young animals, breast-feeding is not recommended during treatment with these medicines.

Children—Use is not recommended for infants or children younger than 18 years of age since fluoroquinolones have been shown to cause bone development problems in young animals. However, your doctor may choose to use one of these medicines if other medicines cannot be used.

Older adults—These medicines have been tested and, in effective doses, have not been shown to cause different side effects or problems in older people than they do in younger adults.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking a fluoroquinolone, it is especially important that your health care professional know if you are taking any of the following:

• Aminophylline or
• Oxtriphylline (e.g., Choledyl) or
• Theophylline (e.g., Elixophyllin, Theo-Dur)—Ciprofloxacin, enoxacin, and norfloxacin may increase the chance of side effects of aminophylline, oxtriphylline, or theophylline

• Amiodarone (e.g., Cordarone) or
• Astemizole (e.g., Hismanal) or
• Bepridil (e.g., Vascor) or
• Cisapride (e.g., Propulsid) or
• Disopyramide (e.g., Norpace) or
• Erythromycin (e.g., E-Mycin) or
• Pentamidine (e.g., NebuPent) or
• Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g., Ormazine, Thorazine Spansule, Thor-Prom], fluphenazine [e.g., Permitil, Prolixin], mesoridazine [e.g., Serentil], methotrimeprazine [e.g., Nozinan], pericyazine [e.g., Neuleptil], perphenazine [e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine [e.g., Primazine, Sparine], thioridazine [e.g., Mellaril], trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin]) or
• Procainamide (e.g., Pronestyl) or
• Quinidine (e.g., Quinidex) or
• Sotalol (e.g., Sotacor) or
• Terfenadine (e.g., Seldane) or
• Tricyclic antidepressants (amitriptyline [e.g., Elavil, Endep], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Norpramin], doxepin [e.g., Sinequan], imipramine [e.g., Norfranil, Tipramine, Tofranil], nortriptyline [e.g., Aventyl, Pamelor], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil])—Use of these medicines with gatifloxacin, levofloxacin, moxifloxacin or sparfloxacin may cause heart problems, such as an irregular heartbeat

• Antacids, aluminum-, calcium-, and/or magnesium-containing, or
• Didanosine (e.g., Videx, ddI) or
• Iron supplements or
• Sucralfate (e.g., Carafate)—Antacids, didanosine, iron, or sucralfate may keep any of the fluoroquinolones from working properly. Ciprofloxacin may be taken 2 hours before or 6 hours after these medicines. Levofloxacin or norfloxacin may be taken 2 hours before or 2 hours after these medicines. Moxifloxacin may be taken 4 hours before or 8 hours after these medicines.

• Caffeine—Ciprofloxacin, enoxacin, and norfloxacin may increase the chance of side effects of caffeine; caffeine should not be taken during treatment with enoxacin

• Phenytoin (e.g., Dilantin)—Ciprofloxacin may keep phenytoin from working properly

• Warfarin (e.g., Coumadin)—Ciprofloxacin, levofloxacin, and norfloxacin may increase the effect of warfarin, increasing the chance of bleeding

Other medical problems—The presence of other medical problems may affect the use of fluoroquinolones. Make sure you tell your doctor if you have any other medical problems, especially:

• Brain or spinal cord disease, including hardening of the arteries in the brain or epilepsy or other seizures—Fluoroquinolones may cause nervous system side effects

• Diabetes mellitus (sugar diabetes)—Levofloxacin may cause changes in blood sugar, which could lead to problems in controlling blood sugar

• Diarrhea—May be a sign of colon problems and taking fluoroquinolones could make this problem worse. Your doctor will want to check you before you begin taking your medicine.

• Glucose-6-phosphate dehydrogenase activity defect (problem with an enzyme that your body makes)—If you have this condition and you take a fluoroquinolone, you could have problems with anemia.

• Heart disease—Gatifloxacin, lomefloxacin, moxifloxacin or sparfloxacin may make this problem worse

• Kidney disease or
• Liver disease—Patients with kidney disease or liver disease may have an increased chance of side effects with any of the fluoroquinolones

• Myasthenia gravis (muscle disease)—This condition may become worse when taking a fluoroquinolone and cause your respiratory muscles to become weak which is life-threatening. Be sure and tell your doctor if you have this condition.

• Sensitivity of the skin to sunlight (previous)—Patients taking sparfloxacin or any of the other fluoroquinolones may have an increased risk of severe reactions to sunlight

• Tendinitis (previous)—Fluoroquinolones may increase the risk of tendon injury