Cipro I V Drug Information

FLUOROQUINOLONES (Systemic)

Some frequently used brand names are:

In the U.S.—

• Avelox ⁶
• Cipro ¹
• Cipro I.V. ¹
• Floxin ⁸
• Floxin I.V. ⁸
• Levaquin ⁴
• Maxaquin ⁵
• Noroxin ⁷
• Tequin ³

In Canada—

• Cipro ¹
• Cipro I.V. ¹
• Floxin ⁸
• Levaquin ⁴
• Noroxin ⁷

Category

• Antibacterial, systemic—Ciprofloxacin; enoxacin; gatifloxacin; levofloxacin; lomefloxacin; moxifloxacin; norfloxacin; ofloxacin; sparfloxacin

Description

Fluoroquinolones (flu-roe-KWIN-a-lones) are used to treat bacterial infections in many different parts of the body. They work by killing bacteria or preventing their growth. However, these medicines will not work for colds, flu, or other virus infections. Fluoroquinolones may also be used for other problems as determined by your doctor.

Fluoroquinolones are available only with your doctor's prescription, in the following dosage forms:

• Oral
• Ciprofloxacin
  • Extended-release tablets (U.S. and Canada)
  • Oral suspension (U.S.)
  • Tablets (U.S. and Canada)
• Enoxacin
  • Tablets (U.S.)
• Gatifloxacin
  • Oral suspension (U.S.)
  • Tablets (U.S.)
• Levofloxacin
  • Oral solution (U.S.)
  • Tablets (U.S. and Canada)
• Lomefloxacin
  • Tablets (U.S.)
• Moxifloxacin
  • Tablets (U.S.)
• Norfloxacin
  • Tablets (U.S. and Canada)
• Ofloxacin
  • Tablets (U.S. and Canada)
• Sparfloxacin
  • Tablets (U.S.)

• Parenteral
• Ciprofloxacin
  • Injection (U.S. and Canada)
• Gatifloxacin
  • Injection (U.S.)
• Levofloxacin
  • Injection (U.S. and Canada)
• Moxifloxacin
  • Injection (U.S.)
• Ofloxacin
  • Injection (U.S.)

Before Using This Medicine

When deciding if it's worth using a medicine, the risk of taking it must be carefully weighed against the benifit it can do. This is the decision you and your doctor are to make together. Concerning the fluoroquinolones, the following aspects should be taken into account:

Allergies—Inform your doctor if you have ever experienced any unusual or allergic reaction to any of the fluoroquinolones or to any related medicines such as cinoxacin (e.g., Cinobac) or nalidixic acid (e.g., NegGram). Also tell your doctor if you are allergic to any other substances, like foods, preservatives, dyes.

Pregnancy—No studies have been conducted in humans. However, use is not recommended during pregnancy since fluoroquinolones have been reported to cause bone development problems in young animals.

Breast-feeding—Some of the fluoroquinolones are known to pass into human breast milk. Since fluoroquinolones have been reported to cause bone development problems in young animals, breast-feeding is not recommended during treatment with these medicines.

Children—Use is not recommended for infants or children younger than 18 years of age since fluoroquinolones have been shown to cause bone development problems in young animals. However, your doctor may choose to use one of these medicines if other medicines cannot be used.

Older adults—These medicines have been tested and, in effective doses, have not been shown to cause different side effects or problems in older people than they do in younger adults.

Other medicines—Although some medicines should not be used together at all, there are cases when 2 different medicines maybe used together even if an interaction might occur. In such cases, your doctor may advise you to change the dose, or other precautions may be required. When you are taking a fluoroquinolone, it is essential to tell your health care professional if you are taking any of the following:

• Aminophylline or
• Oxtriphylline (e.g., Choledyl) or
• Theophylline (e.g., Elixophyllin, Theo-Dur)—Ciprofloxacin, enoxacin, and norfloxacin may increase the chance of side effects of aminophylline, oxtriphylline, or theophylline

• Amiodarone (e.g., Cordarone) or
• Astemizole (e.g., Hismanal) or
• Bepridil (e.g., Vascor) or
• Cisapride (e.g., Propulsid) or
• Disopyramide (e.g., Norpace) or
• Erythromycin (e.g., E-Mycin) or
• Pentamidine (e.g., NebuPent) or
• Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g., Ormazine, Thorazine Spansule, Thor-Prom], fluphenazine [e.g., Permitil, Prolixin], mesoridazine [e.g., Serentil], methotrimeprazine [e.g., Nozinan], pericyazine [e.g., Neuleptil], perphenazine [e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine [e.g., Primazine, Sparine], thioridazine [e.g., Mellaril], trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin]) or
• Procainamide (e.g., Pronestyl) or
• Quinidine (e.g., Quinidex) or
• Sotalol (e.g., Sotacor) or
• Terfenadine (e.g., Seldane) or
• Tricyclic antidepressants (amitriptyline [e.g., Elavil, Endep], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Norpramin], doxepin [e.g., Sinequan], imipramine [e.g., Norfranil, Tipramine, Tofranil], nortriptyline [e.g., Aventyl, Pamelor], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil])—Use of these medicines with gatifloxacin, levofloxacin, moxifloxacin or sparfloxacin may cause heart problems, such as an irregular heartbeat

• Antacids, aluminum-, calcium-, and/or magnesium-containing, or
• Didanosine (e.g., Videx, ddI) or
• Iron supplements or
• Sucralfate (e.g., Carafate)—Antacids, didanosine, iron, or sucralfate may keep any of the fluoroquinolones from working properly. Ciprofloxacin may be taken 2 hours before or 6 hours after these medicines. Levofloxacin or norfloxacin may be taken 2 hours before or 2 hours after these medicines. Moxifloxacin may be taken 4 hours before or 8 hours after these medicines.

• Caffeine—Ciprofloxacin, enoxacin, and norfloxacin may increase the chance of side effects of caffeine; caffeine should not be taken during treatment with enoxacin

• Phenytoin (e.g., Dilantin)—Ciprofloxacin may keep phenytoin from working properly

• Warfarin (e.g., Coumadin)—Ciprofloxacin, levofloxacin, and norfloxacin may increase the effect of warfarin, increasing the chance of bleeding

Other medical problems—The existence of other medical problems may influence the use of /fluoroquinolones. You should tell your doctor if you have any other medical problems, in particular::

• Brain or spinal cord disease, including hardening of the arteries in the brain or epilepsy or other seizures—Fluoroquinolones may cause nervous system side effects

• Diabetes mellitus (sugar diabetes)—Levofloxacin may cause changes in blood sugar, which could lead to problems in controlling blood sugar

• Diarrhea—May be a sign of colon problems and taking fluoroquinolones could make this problem worse. Your doctor will want to check you before you begin taking your medicine.

• Glucose-6-phosphate dehydrogenase activity defect (problem with an enzyme that your body makes)—If you have this condition and you take a fluoroquinolone, you could have problems with anemia.

• Heart disease—Gatifloxacin, lomefloxacin, moxifloxacin or sparfloxacin may make this problem worse

• Kidney disease or
• Liver disease—Patients with kidney disease or liver disease may have an increased chance of side effects with any of the fluoroquinolones

• Myasthenia gravis (muscle disease)—This condition may become worse when taking a fluoroquinolone and cause your respiratory muscles to become weak which is life-threatening. Be sure and tell your doctor if you have this condition.

• Sensitivity of the skin to sunlight (previous)—Patients taking sparfloxacin or any of the other fluoroquinolones may have an increased risk of severe reactions to sunlight

• Tendinitis (previous)—Fluoroquinolones may increase the risk of tendon injury

Proper Use of This Medicine

Do not take fluoroquinolones if you are pregnant. Do not give fluoroquinolones to infants, children, or teenagers unless otherwise directed by your doctor. These medicines have been shown to cause bone development problems in young animals.

Fluoroquinolones should be used only to treat bacterial infections and not viral infections like the common cold.

To help clear up your infection completely, keep taking your medicine for the full time of treatment , even if you begin to feel better after a few days. If you stop taking this medicine too soon, your symptoms may return.

Fluoroquinolones are best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day , unless you are otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects of ciprofloxacin and norfloxacin.

Enoxacin or norfloxacin should be taken on an empty stomach .

Ciprofloxacin, gatifloxacin, levofloxacin, lomefloxacin, moxifloxacin, ofloxacin, or sparfloxacin may be taken with meals or on an empty stomach. Ciprofloxacin should NOT be taken with dairy products or calcium-fortified juices alone, but may be taken with a meal that contains these products

This medicine works best when there is a constant amount in the blood or urine. To help keep the amount constant, do not miss any doses. Also, it is best to take the doses at evenly spaced times, day and night . For example, if you are to take two doses a day, the doses should be spaced about 12 hours apart. If this interferes with your sleep or other daily activities, or if you need help in planning the best times to take your medicine, check with your health care professional.

If you need to take this medicine for anthrax, your doctor will want you to begin taking it as soon as possible after you are exposed to anthrax.

Dosing—The dose of fluoroquinolones will vary for different patients. Adhere to the orders of your doctor or the instructions on the label . The information below includes only the average doses of fluoroquinolones. Your dose may be different if you have kidney disease. If your dose differs, you should not change it unless your doctor tells you to do so.

The number of tablets or amount of oral suspension that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using a fluoroquinolone .

• For ciprofloxacin
• For oral dosage form (extended-release tablets):
  • Adults: 500 to 1000 milligrams (mg) every twenty-four hours for three to fourteen days, depending on the medical problem being treated.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.
• For oral dosage form (oral suspension or tablets):
  • Adults: 100 to 750 milligrams (mg) every twelve hours for three to twenty-eight days, depending on the medical problem being treated. Bone and joint infections are usually treated for at least four to six weeks. Gonorrhea is usually treated with a single oral dose of 250 mg. Inhalational anthrax is usually treated for sixty days with 500 mg every twelve hours.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers, except in the case of inhalational anthrax. Inhalational anthrax is usually treated for sixty days with 15 mg per kilogram (kg) (6.8 mg per pound) of body weight every twelve hours.
• For injection dosage form:
  • Adults: 200 to 400 mg every eight to twelve hours.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers, except in the case of inhalational anthrax. Inhalational anthrax is usually treated for sixty days with 10 mg per kg (4.5 mg per pound) of body weight every twelve hours.

• For enoxacin
• For oral dosage form (tablets):
  • Adults: 200 to 400 mg every twelve hours for seven to fourteen days, depending on the medical problem being treated. Gonorrhea is usually treated with a single oral dose of 400 mg.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.

• For gatifloxacin
• For oral dosage form (oral suspension or tablets):
  • Adult: 200 to 400 mg every twenty four hours for seven to fourteen days, depending on the medical problems being treated. Gonorrhea and certain bladder infection are usually treated with a single oral dose of 400 mg.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.
• For injection dosage form:
  • Adults: 200 to 400 mg every twenty four hours for seven to fourteen days, depending on the medical problems being treated. Gonorrhea and certain bladder infection are usually treated with a single oral dose of 400 mg.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.

• For levofloxacin
• For oral dosage form (tablets):
  • Adults: 250 to 750 mg once a day for three to twenty-eight days, depending on the medical problem being treated.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.
• For injection dosage form:
  • Adults: 250 to 750 mg, injected slowly into a vein, once a day for three to twenty-eight days, depending on the medical problem being treated.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.

• For lomefloxacin
• For oral dosage form (tablets):
  • Adults: 400 mg once a day for three to fourteen days, depending on the medical problem being treated.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.

• For moxifloxacin
• For oral dosage form (tablets):
  • Adult: 400 mg once a day for five to fourteen days, depending on the medical problem being treated.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.
• For injection dosage form:
  • Adult: 400 mg injected in a vein once a day for five to fourteen days, depending on the medical problem being treated.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.

• For norfloxacin
• For oral dosage form (tablets):
  • Adults: 400 mg every twelve hours for three to twenty-eight days, depending on the medical problem being treated. Gonorrhea is usually treated with a single oral dose of 800 mg.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.

• For ofloxacin
• For oral dosage form (tablets):
  • Adults: 200 to 400 mg every twelve hours for three to fourteen days, depending on the medical problem being treated. Prostatitis is usually treated for six weeks. Gonorrhea is usually treated with a single oral dose of 400 mg.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.
• For injection dosage form:
  • Adults: 200 to 400 mg, injected slowly into a vein, every twelve hours for three to fourteen days, depending on the medical problem being treated. Prostatitis is usually treated for six weeks. Gonorrhea is usually treated with a single dose of 400 mg.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.

• For sparfloxacin
• For oral dosage form (tablets):
  • Adults: 400 mg on the first day, then 200 mg once a day for an additional nine days.
  • Children up to 18 years of age: This medicine is not recommended for use in infants, children, or teenagers.

Missed dose—If you miss a dose of this medicine, take it as soon as possible. This will help to keep a constant amount of medicine in the blood or urine. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. You should not double doses.

Storage—To store this medicine properly, follow the instructions below:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Ciprofloxacin oral suspension may be refrigerated. However, keep this medicine from freezing.
• Gatifloxacin oral suspension may be stored in the tightly closed bottle in a refrigerator for 14 days. Shake thoroughly prior to each use.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

Precautions While Using This Medicine

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

If you are taking aluminum- or magnesium-containing antacids, didanosine, or sucralfate, do not take them at the same time that you take this medicine . It is best to take these medicines at least 6 hours before or 2 hours after taking ciprofloxacin; at least 8 hours before or 2 hours after taking enoxacin; at least 4 hours after taking gatifloxacin; at least 4 hours before or 4 hours after taking sparfloxacin; at least 2 hours before or 2 hours after taking levofloxacin, norfloxacin, or ofloxacin; at least 4 hours before or 2 hours after taking lomefloxacin, and at least 8 hours before and 4 hours after taking moxifloxacin. These medicines may keep fluoroquinolones from working properly.

If you are taking metal cations such as iron, and multivitamin preparations with zinc, or didanosine (Videx[reg ]) chewable/buffered tablets or the pediatric powder for oral solution take moxifloxacin at least 4 hours before or 8 hours after and take ciprofloxacin at least 2 hours before or 6 hours after taking these medicines.

If you are taking levofloxacin or lomefloxacin, you should not take certain medications which correct a fast, slow or irregular heartbeat. Check with your physician to determine whether you are taking one of these medications.

If you are taking enoxacin, you should not take any caffeine-containing products (e.g., coffee, tea, chocolate, certain carbonated beverages) . Taking any of these caffeine-containing products while you are taking enoxacin may increase the effects of caffeine.

Some people who take fluoroquinolones, especially sparfloxacin, may become more sensitive to sunlight than they are normally. Exposure to sunlight, even for brief periods of time, may cause severe sunburn, or skin rash, redness, itching, or discoloration. When you begin taking this medicine:

• Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible.
• Wear protective clothing, including a hat and sunglasses.
• Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your health care professional.
• Do not use a sunlamp or tanning bed or booth.

Stay out of direct sunlight and artificial light (e.g., sunlamp, tanning bed or booth) for the next 5 days or until the reaction has stopped.

If you get a skin rash or other signs of an allergic reaction, stop taking the fluoroquinolone and check with your doctor .

Fluoroquinolones may also cause some people to become dizzy, lightheaded, drowsy, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that can be dangerous if you are dizzy or are not alert . If these reactions are especially bothersome, check with your doctor.

Fluoroquinolones may rarely cause inflammation or even tearing of a tendon (the cord that attaches muscles to bones). If you get sudden pain in a tendon after exercise (for example, in your ankle, back of the knee or leg, shoulder, elbow, or wrist), stop taking the fluoroquinolone and check with your doctor . Rest and do not exercise until the doctor has made sure that you have not injured or torn the tendon.

If you have pain, burning, tingling, numbness and/or weakness, stop taking the fluoroquinolone and check with your doctor.

For patients with diabetes taking insulin or diabetes medicine by mouth: Levofloxacin may cause hypoglycemia (low blood sugar) in some patients. Symptoms of low blood sugar must be treated before they lead to unconsciousness (passing out) . Different people may feel different symptoms of low blood sugar. If you experience symptoms of low blood sugar, stop taking levofloxacin and check with your doctor right away:

• Symptoms of low blood sugar can include: Anxious feeling, behavior change similar to being drunk, blurred vision, cold sweats, confusion, cool pale skin, difficulty in concentrating, drowsiness, excessive hunger, headache, nausea, nervousness, rapid heartbeat, shakiness, unusual tiredness or weakness.

For patients with low potassium levels: levofloxacin may increase your risk of experiencing a fast, slow or irregular heartbeat.

Side Effects of This Medicine

Alongside with its expected effects, any medicine may be the cause of some unwanted effects. Although not all of these side effects may happen, if they do happen they may require medical attention.

Check with your doctor immediately if any of the following side effects occur:

Other side effects that may occur generally do not require any medical attention. These side effects may disappear in the course of treatment as your body gets used to the medicine. Nevertheless, inform your doctor if any of the side effects below persist or became annoying:

Other side effects not mentioned above may also happen in some patients. If you notice any other effects, tell your doctor about it.

Additional Information

Once a drug has been approved for marketing for certain cases, experience may show that it can also be applied to treatment of some other medical problems. Although these uses are not included in product labeling, fluoroquinolones are used in certain patients with the following medical conditions:

• Chancroid
• Pulmonary exacerbations (airway infections) in cystic fibrosis

There is no additional information concerning proper use, precautions, or side effects for these uses other than the above.